Chylomicronemia Caused by Lipoprotein Lipase Gene Mutation Related to a Hyper-response of Insulin Secretion to Glucose.
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- TANAKA Shu
- The Third Department of Internal Medicine, Nippon Medical School
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- TANABE Yoshihiro
- The Department of Internal Medicine, Shimodate-Shimin Hospital
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- TAMURA Hideki
- The Third Department of Internal Medicine, Nippon Medical School
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- ISHII Shinya
- The Third Department of Internal Medicine, Nippon Medical School
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- SHUTO Yuji
- The Third Department of Internal Medicine, Nippon Medical School
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- KAMEGAI Jun
- The Third Department of Internal Medicine, Nippon Medical School
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- SUGIHARA Hitoshi
- The Third Department of Internal Medicine, Nippon Medical School
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- KOBAYASHI Masafumi
- The Third Department of Internal Medicine, Nippon Medical School
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- WAKABAYASHI Ichiji
- The Third Department of Internal Medicine, Nippon Medical School
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- MURANO Takeyoshi
- Clinical Laboratory Medicine, Sakura Hospital, School of Medicine, Toho University
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- SHIRAI Koji
- Clinical Laboratory Medicine, Sakura Hospital, School of Medicine, Toho University
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- OIKAWA Shinichi
- The Third Department of Internal Medicine, Nippon Medical School
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A 39-year-old man with lipoprotein lipase (LPL) deficiency (height 177.7 cm, body weight 67 kg, and body mass index 21.2 kg/m2) showed severe hypertriglyceridemia (2, 032 mg/dl). LPL activity and concentration were markedly low in postheparin plasma. LPL gene analysis revealed a homozygous mutation, Asp204 → Glu in exon 5. Fasting plasma glucose (81 mg/dl) and insulin (2.7 (μU/ml) levels were normal. Plasma glucose pattern during oral glucose (75 g) tolerance test was normal, however 30 minutes after glucose-loading the insulin secretion unexpectedly increased to 89.4 μU/ml. These data suggested that chylomicronemia might be related to a hyper-response of insulin secretion to glucose without obesity.<br>(Internal Medicine 41: 300-303, 2002)
収録刊行物
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- Internal Medicine
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Internal Medicine 41 (4), 300-303, 2002
一般社団法人 日本内科学会
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詳細情報 詳細情報について
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- CRID
- 1390001204868675840
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- NII論文ID
- 10008354782
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- NII書誌ID
- AA10827774
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- COI
- 1:STN:280:DC%2BD383lsVCjtA%3D%3D
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- ISSN
- 13497235
- 09182918
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- NDL書誌ID
- 6262809
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- PubMed
- 11993791
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可