大腸sm癌・mp癌におけるMatrix Metalloproteinase-9(MMP-9)発現と臨床病理学的所見の検討  [in Japanese] The Expression of MMP-9 in pT1 and pT2 Colorectal Carcinoma and its Relationship with Malignant Potential  [in Japanese]

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Author(s)

    • 奥山 隆 OKUYAMA T.
    • 獨協医科大学越谷病院外科 Department of Surgery, Koshigaya Hospital, Dokkyo University School of Medicine

Abstract

癌の浸潤や転移にはMatrix Metalloproteinases(MMPs)による細胞外マトリクスの分解が重要な役割を果たしていると考えられている.今回,基底膜破壊に関与するとされるMMP-9と,大腸癌の臨床病理学的所見との関連を検討した.手術で切除された高分化型大腸sm癌25例・mp癌25例にMMP-9の免疫組織化学染色を施行した.MMP-9は癌先進部に接する間質細胞(主にマクロファージ)に発現しており,発現細胞の頻度から-・+・++・+++の4段階に発現程度を評価した.MMP-9の発現程度はリンパ節転移の有無との有意な関連は認められなかったが,sm癌よりもmp癌で高度であり,リンパ管侵襲,浸潤性発育,細胞異型度が高異型度,組織型変化,buddingといった高悪性度を示唆する病変で高度であった.以上よりMMP-9の発現は大腸sm癌・mp癌の悪性度と関連があると考えられた.

Matrix metalloproteinase-9 (MMP-9) is suspected to play a role in the invasion and metastasis of colorectal carcinoma. In this study, we explored the relationship between the expression of MMP-9 and clinicopathological findings in pTl and pT2 colorectal carcinoma. We studied surgically resected specimens of 25 pT1 and 25 pT2 colorectal well differentiated adenocarcinomas, using hematoxylin-eosin (H-E) staining and immunohistochemical staining for MMP-9. The expression of MMP-9 in mononuclear cells (mainly in macrophages) in the cancer stroma at the invasive front was classified into four grades according to the incidence of MMP-9 positive cells : absent (-), few (+), intermediate (2+), or many (3+). MMP-9 positive cells were absent in 15 lesions, few in 10 lesions, intermediate in 10 lesions, and many in 15 lesions. MMP-9 positive cells were more in pT2 lesions than in pT1 lesions. Although the incidence of MMP-9 positive cells did not correlate with lymphnode metastasis, it correlated with cellular atypia, change in differentiation, pattern of invasion, budding, and lymphatic invasion. These results may suggest that the expression of MMP-9 in stromal cells at the invasive front correlates with malignant potential of pTl and pT2 colorectal carcinoma.

Journal

  • Nippon Daicho Komonbyo Gakkai Zasshi

    Nippon Daicho Komonbyo Gakkai Zasshi 55(1), 9-15, 2002-01

    The Japan Society of Coloproctology

References:  32

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008385964
  • NII NACSIS-CAT ID (NCID)
    AN00195100
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    00471801
  • Data Source
    CJP  CJPref  J-STAGE 
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