久留米大学における最近6年間のボーエン病およびボーエン癌100例の統計 : 福岡県筑後地方における砒素汚染井戸の存在との関連について  [in Japanese] A Statistical Study of 100 Cases of Bowen's Disease and Bowen Carcinoma at Kurume University Hospital from 1995 to 2000 : Possible relationships between Intake of Water from Arsenic-polluted Wells and High Frequency of the Disease in Chikugo Area  [in Japanese]

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Abstract

久留米大学医学部皮膚科において1995年1月から2000年12月までの6年間に経験したボーエン病およびボーエン癌全100例の統計的検討を行った.性別は男性58例,女性42例,男女比は1.4:1で,平均年齢は74.0歳であった.外来新患者数に対する頻度は0.54%と他施設から報告されている頻度に比べ高かった.部位別発生頻度では下肢,躯幹,足部の順で非露光部に多かった.多発例は15例であったが病歴上,後述する井戸水以外,あきらかな砒素への曝露歴はなかった.一方,ほぼ全例に飲料水としての井戸水の利用歴があった.ボーエン病以外の悪性腫瘍の合併は内臓悪性腫瘍11例,皮膚悪性腫瘍6例にみとめられた.福岡県筑後地方では地下水の砒素汚染が判明し,福岡県の調査が行われている.今回検討した100例中,筑後地方の住民は70例であり,県の調査による高濃度砒素(0.01 mg/<i>l</i>以上)検出地域の住民は52例で,74.3%に相当していた.以上から筑後地方での人口の高齢化に加え,地下水の砒素汚染が当地区におけるボーエン病の多発傾向に関与している可能性が考えられた.

A statistical study of 100 cases diagnosed as Bowen's disease or Bowen carcinoma at Kurume University Hospital between January of 1995 and December of 2000 was performed. These 100 patients included 58 men and 42 women (the male : female ratio was 1.4 : 1), and the average age of first visit was 74.0 years old. The frequency of Bowen's disease and Bowen carcinoma among newly visiting outpatients was 0.54%, which was higher than the frequencies reported by other institutes in Japan. Fifteen patients had multiple lesions, among whom eleven were associated with internal malignancies and six with other cutaneous malignant tumors. Although clear arsenic exposure as an etiologic factor could not be confirmed, almost all the cases had consumed water from wells. Kurume University Hospital is located in the Chikugo area of Fukuoka prefecture, where arsenic pollution of subterranean water has been proven, and the causes of this pollution are currently under investigation. The majority (74.3%) of the patients from the Chikugo area were residing in areas of higher concentrations of arsenic in the wells. These results suggested a possible relationship between intake of water from arsenic-polluted wells and the high frequency of the disease in the Chikugo area.

Journal

  • The Japanese Journal of Dermatology

    The Japanese Journal of Dermatology 112(1), 29-35, 2002-01-20

    Japanese Dermatological Association

References:  20

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008386448
  • NII NACSIS-CAT ID (NCID)
    AN00196602
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    0021499X
  • NDL Article ID
    025120373
  • NDL Call No.
    Z19-202
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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