A Case of Early Breast Cancer (t1n0) with Meningeal Carcinomatosis.

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  • 早期乳癌（ｔ１ｎ０）の髄膜播種転移の１例

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Abstract

A 50-year-old premenoposal woman was seen at the department because of a left breast tumor. A soft tumor measuring 2cm in diameter in A-area of the left breast and soft lymph nodes in the left axilla were palpable. We recognized the tumor as TlNlaMX and performed a modified radical mastectomy (Bt+Ax). Histological findings revealed that the tumor was 1.5×1.2cm, invasive ductal carcinoma, solid tubular, f+, tlnOMX. Estrogen receptor and progesterone receptor of the tumor were not able to be examined. Postoperative chemotherapy with 5-FU and toremifene was conducted, but she had recurrent nests near the operation scar 10 months after the operation. She was treated with electron therapy. Systemic bone scintigraphy performed just after this treatment revealed multiple bone metastases. Chemotherapy with 5-FU, epirubicin and cyclophosphamide was started. Severe headache, conscious disorder and convulsion developed and she was re-admitted to the hospital 13 months after the operation. Although head CT images revealed no specific findings, neck stiffness became apparent and meningeal tap revealed meningeal carcinomatosis. Her general condition rapidly deteriorated and she died of recurrence of the breast cancer 9 days after the second admission.

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