A Case of Hepatocellular Carcinoma Associated with Congenital Antithrombin III Deficiency.

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  • 先天性アンチトロンビンＩＩＩ欠乏症に合併した肝細胞癌の１例

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Abstract

This paper presents a case of hepatocellular carcinoma associated with congenital antithrombin III (ATIII) deficiency which was successfully operated on. A 65-year-old man was admitted to the hospital bacause of abdominal pain. The patient had a history of thrombosis of the lower leg and his two sons had been diagnosed as having congenital ATIII deficiency. Abdominal ultrasonography demonstrated a tumor in the right lobe of the liver. With close exploration, it was diagnosed as HCV positive chronic hepatitis and hepatocellular carcinoma. His preoperative ATIII activity was only 22% of the normal value. ATIII concentrates were administered to prevent perioperative thrombosis and a hepatectomy of the anterior segment was performed. Postoperatively not only ATIII concentrates but also fresh frozen plasma and protease inhibitor were administered, so that no complications including venous trombosis occurred during the postoperative course.

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