A Case of Dubin-Johnson Syndrome Associated with Retroperitoneal Leiomyosarcoma.

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  • Ｄｕｂｉｎ‐Ｊｏｈｎｓｏｎ症候群に合併した後腹膜平滑筋肉腫の１例

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Abstract

We report a case of Dubin-Johnson syndrome associated with retroperitoneal leiomyosarcoma. A 72-year-old woman undergoing retroperitoneal leiomyosarcoma resection 2 years previously, had a history of jaundice since young. Abdominal CT scans revealed a recurrent retroperitoneal tumor invading the pancreas, stomach, and mediastinum. She was admitted for tarry stool and dizziness. Endoscopy showed an easily bleeding tumor in the stomach. Total bilirubin was 3.2mg/dl and direct bilirubin 2.6mg/dl. Continued bloody stool led us to conduct a laparotomy, where liver size was found to be within normal limits and the liver brownish-black. The retroperitoneal tumor was resected together with the stomach and distal pancreas. The mediastinal tumor was resected through the diaphragm. Microscopic findings showed the tumor to be leiomyosarcoma. Liver biopsy showed coarse brown granules in hepatocytes. The postoperative course was uneventful, without transient bilirubin elevation.

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