Circling Mouse, a Spontaneous Mutant in the Inner Ear.

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  • LEE Jeong Woong
    Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical College College of Agriculture, Animal and Life Science, Kon-Kuk University
  • RYOO Zae Young
    Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical College
  • LEE Eun Ju
    Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical College
  • HONG Sung Hwa
    Department of ORL-HNS, Samsung Medical Center, Sungkyunkwan University
  • CHUNG Won Ho
    Department of ORL-HNS, Samsung Medical Center, Sungkyunkwan University
  • LEE Hoon Taek
    College of Agriculture, Animal and Life Science, Kon-Kuk University
  • CHUNG Kil Saeng
    College of Agriculture, Animal and Life Science, Kon-Kuk University
  • KIM Tae Yoon
    Department of Dermatology, Catholic Research Institutes of Medical Science, Catholic Medical College
  • OH Yang Seok
    Department of Medical Genetics and Experimental Animal Center, College of Medicine, Hallym University
  • SUH Jun Gyo
    Department of Medical Genetics and Experimental Animal Center, College of Medicine, Hallym University

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Abstract

A spontaneous mutant was established in the ICR mouse strain. The affected mice became hyperactive at about 7 days of age, and then showed circling behavior. The body weight decreased significantly 2 weeks after birth, and developmental defects were revealed in the middle ear, cochlea, cochlear nerve, and semicircular canal areas. The mutation was inherited by an autosomal single recessive gene and is referred to as cir.

Journal

  • Experimental Animals

    Experimental Animals 51 (2), 167-171, 2002

    Japanese Association for Laboratory Animal Science

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