A Model for Dextran Sodium Sulfate (DSS)-induced Mouse Colitis : Bacterial Degradation of DSS Does Not Occur after Incubation with Mouse Cecal contents

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Author(s)

Abstract

Germ-free (GF) mice are highly susceptible to dextran sodium sulfate (DSS)-induced colitis in comparison to conventionalized (CVz) mice. It is hypothesized that degradation of DSS by intestinal microflora is involved in the susceptibility to DSS-induced colitis of GF mice. This study evaluates the ability of bacteria in mouse cecal contents (CC) to degrade DSS in vitro, and provides confirmatory evidence that DSS was not degraded when incubated with CC. Our results suggest that intestinal microflora do not contribute directly to the difference in susceptibility of GF mice to DSS-induced colitis through degradation.

Journal

  • Experimental Animals

    Experimental Animals 51(2), 203-206, 2002-04

    Japanese Association for Laboratory Animal Science

References:  18

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008394421
  • NII NACSIS-CAT ID (NCID)
    AA11032321
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13411357
  • NDL Article ID
    6136441
  • NDL Source Classification
    ZS7(科学技術--医学)
  • NDL Call No.
    Z54-H752
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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