Biphasic Hypothermia in Mice Infected with a Parasitic Nematode, Trichinella spiralis

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Author(s)

Abstract

In BALB/c mice infected with Trichinella spiralis, changes in body temperature (Tb) were observed over 35 days after the infection. T. spiralis infection induced hypothermia two times at 7 and 28 days after infection. The initial decrease persisted for about one week with a peak (37.1±0.62°C) around 10 days after the infection, while the later phase persisted for at least one week. Both 10 and 35 days after the infection, there were remarkable decreases in Tb. The serum glucose level of infected mice at 10 days was significantly (p<0.01) decreased compared with that of control mice at the same number of days, while the level in infected mice at 35 days was not decreased. Moreover, the later phase of hypothermia was prevented by the cyclooxygenase inhibitor indomethacin (10 mg/kg i.p.), while the initial phase was not. We conclude that hypothermia was caused by two different mechanisms, involving the effects of hypoglycemia and prostaglandins.

Journal

  • Experimental Animals

    Experimental Animals 51(2), 207-211, 2002-04

    Japanese Association for Laboratory Animal Science

References:  14

Codes

  • NII Article ID (NAID)
    10008394440
  • NII NACSIS-CAT ID (NCID)
    AA11032321
  • Text Lang
    ENG
  • Article Type
    NOT
  • ISSN
    13411357
  • NDL Article ID
    6136446
  • NDL Source Classification
    ZS7(科学技術--医学)
  • NDL Call No.
    Z54-H752
  • Data Source
    CJP  NDL  J-STAGE 
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