脳卒中易発症ラット（ＳＨＲＳＰ）の脳血管障害発症過程解明へのＭＲＩ利用の試み

DOI Web Site PubMed 被引用文献4件

書誌事項

タイトル別名
  • MR imaging of cerebral lesions accompanying stroke in stroke-prone spontaneously hypertensive rats.
  • ノウソッチュウ イハッショウ ラット SHRSP ノ ノウ ケッカン ショウガ

この論文をさがす

抄録

Cerebral lesions accompanying stroke in male stroke-prone spontaneously hypertensive rats (SHRSP, n=10) were examined by both magnetic resonance imaging (MRI) and histological evaluation. T2-weighted MR images (T2-WI), taken 1-2 days after animals showed behavioral hyperactivity, indicated hyperintense regions in the occipital cortex, caudate putamen and/or thalamus. The areas of hyperintensity on T2-WI corresponded to neurodegenerative regions including edema, gliosis, and softening of the tissue. T1-weighted images (T1-WI) did not show any hyperintense regions. Howerer T1-weighted images enhanced by the contrast media Gd-DTPA (Gd-T1-WI) showed hyperintense spots within some of the hyperintense areas on T2-WI, which exhibited neurodegenerative regions such as thrombus, angionecrosis and hemorrhage in addition to the edematous formation. The hyperintense areas on Gd-T1-WI were smaller than those on T2-WI. In some animals, hypointense spots on T2-, T1-and Gd-T1-WI were found within the hyperintense areas, which corresponded to clots. Extensive histological examination did not reveal any additional cerebral degeneration which had not been detected on the MR images. These findings indicate that MRI is useful for detecting and differentiating various types of cerebrovascular disease in this model.

収録刊行物

被引用文献 (4)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ