Involvement of Glutamate Receptors Within the Central Nucleus of the Amygdala in Naloxone-Precipitated Morphine Withdrawal-Induced Conditioned Place Aversion in Rats.

• Watanabe Takeshi

  Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Nakagawa Takayuki

  Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Yamamoto Rie

  Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Maeda Akifumi

  Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Minami Masabumi

  Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Satoh Masamichi

  Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

抄録

Chronic use of morphine leads to physical and psychological dependence. The amygdala is known to be involved in the expression of emotion such as anxiety and fear, and several studies have shown that the central nucleus of the amygdala (CeA) is involved in morphine dependence. In the present study, we investigated the role of glutamate receptors within the CeA in the negative affective component of morphine abstinence by evaluating naloxone-precipitated withdrawal-induced conditioned place aversion (CPA) in morphine-dependent rats. We found that microinjection of the AMPA/kainate-glutamate-receptor antagonist CNQX (30 nmol/side) into the bilateral CeA significantly attenuated the naloxone-precipitated withdrawal-induced CPA, as well as several somatic signs, in morphine-dependent rats, without preference or aversive effects by itself in non-dependent rats. Furthermore, microinjection of the non-competitive NMDA-receptor antagonist MK-801 (30 nmol/side) or competitive NMDA-receptor antagonist <sc>D</sc>-CPPene (0.01 and 0.1 nmol/side) into the CeA significantly attenuated the naloxone-precipitated morphine withdrawal-induced CPA, but not somatic withdrawal signs. These results suggest that the activation of AMPA/kainate and NMDA receptors within the CeA play a crucial role in the negative affective component of morphine abstinence.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 88 (4), 399-406, 2002

  公益社団法人 日本薬理学会

キーワード

• Morphine withdrawal
• Conditioned place aversion
• Central nucleus of amygdala
• Glutamate
• Morphine dependence

詳細情報

• CRID: 1390001204285822464
• NII論文ID: 10008415057
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.88.399
• COI: 1:STN:280:DC%2BD38zgsFGmsQ%3D%3D
• ISSN: 13473506
• ISSN: 00215198
• ISSN: http://id.crossref.org/issn/00215198
• NDL書誌ID: 6263192
• PubMed: 12046982
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6263192
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819301623?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819301623?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2002282335
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
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