ヒト肝臓特異的新規有機アニオントランスポーターＬＳＴ‐１の単離とその機能解析

• 阿部 高明

  東北大学医学部生体情報学助手

書誌事項

タイトル別名

• Identification and Characterization of Human Liver-Specific Organic Anion Transporter LST-1.

抄録

We have isolated a novel liver-specific organic anion transporter, LST-1, that is expressed exclusively in the human, rat and mouse liver. LST-1 is a new gene family located between the organic anion transporter family and prostaglandin transporter. LST-1 transport taurocholate (Km; 13.6μM) in a sodium- independent manner. LST-1 also shows broad substrate specificity. It transports conjugated steroids (dehydroepiandrosterone sulfate, estradiol-17β-glucuronide and estrone-3-sulfate), eicosanoids (prostaglandin E₂, thromboxane B₂, leukotriene C₄, leukotriene E₄), and thyroid hormones, reflecting hepatic multispecificity. LST-1 is probably the most important transporter in the human liver for clearance of bile acids and organic anions since hepatic levels of another organic anion transporter, OATP is very low. We have also isolated rat counter part, rlst-1. rlst-1 is excusively expressed in the liver and in both the bile duct ligation model and the cecum ligation and puncture model, the mRNA expression levels of rlst-1 were downregulate, suggesting rlst-1 may be under feedback regulation of cholestasis by biliary obstruction and/or sepsis.

収録刊行物

• 薬物動態

  薬物動態 15 (2), 177-181, 2000

  日本薬物動態学会

キーワード

• 有機アニオントランスポーター
• 中状腺ホルモン
• 胆汁酸
• ステロイド
• LST-1

詳細情報

• CRID: 1390001204670262528
• NII論文ID: 130003561134
• NII論文ID: 10008416097
• NII書誌ID: AN10144117
• DOI: 10.2133/dmpk.15.177
• ISSN: 09161139
• Web Site: http://www.jstage.jst.go.jp/article/dmpk1986/15/2/15_2_177/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000211507
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可