薬物相互作用ワーキンググループ　　ＨＡＢ協議会データベース

• 池田 敏彦

  三共株式会社薬物動態研究所

書誌事項

タイトル別名

• Drug Interaction Working Group. HAB Database.

抄録

The Drug Interaction Working Group consisting of 31 Japanese pharmaceutical companies was organized to generate a drug interaction database by the Human and Animal Bridge Discussion Group. Protocols for the assay methods of 10 isoforms of human liver cytochrome P450 (CYP1A1 & 2, CYP2A6, CYP2B6, CYP2C8 & 9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4) were provided, and the collection of the data on inhibition of these isoforms (Ki) by drugs already on the market has been started. A common, human liver microsome pool, which was prepared from 10 liver samples supplied by the National Disease Research Interchange in the USA, is being used for this measurement. In the case of no inhibition, the highest concentration of the test article examined is to be reported. As well, information on plasma concentration, plasma protein binding ratios in humans, the main metabolic pathway and the drug-metabolizing enzymes for the drug in question are being collected. As a result, the database will be able to automatically calculate, using the above-described parameters, a theoretical estimate of the magnitude of the drug interaction caused by the enzyme inhibition.

収録刊行物

• 薬物動態

  薬物動態 15 (3), 255-259, 2000

  日本薬物動態学会

キーワード

• Drug interaction
• Human liver microsome
• Enzyme inhibition
• Cytochrome P450
• Database, Ki

詳細情報

• CRID: 1390282679644484224
• NII論文ID: 10008416305
• NII書誌ID: AN10144117
• DOI: 10.2133/dmpk.15.255
• ISSN: 09161139
• Web Site: http://www.jstage.jst.go.jp/article/dmpk1986/15/3/15_3_255/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2001046159
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可