ＰＫ／ＰＤモデリングの実際

• 松本 宜明

  昭和薬科大学

• 清水 万紀子

  昭和薬科大学

• 福岡 正道

  昭和薬科大学

書誌事項

タイトル別名

• Practical Application of Pharmacokinetic-Pharmacodynamic Modeling.

抄録

Recently, an increasing number of pharmaceutical scientists and clinical pharmacists have begun to focus on pharmacodynamics, which relates the time course of drug concentration to the time course of pharmacological effects. An integration knowledge of pharmacokinetics and pharmacodynamics is essential for the development of rational pharmacotherapeutics because pharmacodynamics and pharmacokinetics are able to determines the drug concentration required to produce the desired therapeutic effect and the drug dose regimen required to achieve the targeted drug concentration, respectively, by using various models. The general principles of the drug effect model are based on the reversible direct and indirect models. In this review, various models in terms of the time course of drug effects are presented and discussed.

収録刊行物

• 薬物動態

  薬物動態 15 (5), 452-460, 2000

  日本薬物動態学会

キーワード

• Pharmacokinetics
• Pharmacodynamics
• Modeling
• Direct model
• Indirect model
• Effect compartment model

詳細情報

• CRID: 1390282679646991616
• NII論文ID: 10008416582
• NII書誌ID: AN10144117
• DOI: 10.2133/dmpk.15.452
• ISSN: 09161139
• Web Site: http://www.jstage.jst.go.jp/article/dmpk1986/15/5/15_5_452/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2001140166
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可