A Nuclear Factor-κB Inhibitor BAY 11-7082 Suppresses Endothelin-1 Production in Cultured Vascular Endothelial Cells

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Author(s)

Abstract

BAY 11-7082, an inhibitor of nuclear factor-κB (NF-κB), which prevents a step of the phosphorylation of inhibitory protein IκB bound to NF-κB, suppressed basal and tumor necrosis factor (TNF)-α-induced prepro endothelin (ET)-1 mRNA expression and NF-κB activation in cultured vascular endothelial cells. BAY 11-7082 significantly decreased basal and TNF-α-induced ET-1 release from endothelial cells. These results indicate that the inhibition of NF-κB activation contributes to the suppressive effect of BAY 11-7082 on ET-1 gene expression and ET-1 release, thereby suggesting that NF-κB plays an important role in the regulation of ET-1 production.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 89(1), 81-84, 2002-05-01

    The Japanese Pharmacological Society

References:  15

Cited by:  3

Codes

  • NII Article ID (NAID)
    10008431136
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    6170965
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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