Modulation by 5-HT_<2A> Receptors of Aggressive Behavior in Isolated Mice

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Author(s)

Abstract

The present study examines whether isolation-rearing affects sensitivity of 5-hydroxytryptamine (5-HT)<sub>2A</sub> receptors and the functional interaction between 5-HT<sub>1A</sub> and 5-HT<sub>2A</sub> receptors in mice. The 5-HT<sub>2A</sub>-receptor agonist (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI)-induced head twitch response was significantly greater in isolated mice than in grouped mice. DOI increased isolation-induced aggressive behavior, and the 5-HT<sub>2A</sub>-receptor antagonist ritanserin decreased it. The 5-HT<sub>1A</sub>-receptor agonist (<i>S</i>)-5-[3-[(1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-benzodioxole HCl (MKC-242) inhibited the DOI-enhanced aggressive behavior. MKC-242 inhibited DOI-induced head twitch response. These findings suggest that 5-HT<sub>2A</sub> receptors play a role in aggressive behavior in isolated mice and imply that the antiaggressive effect of MKC-242 may be mediated partly by the inhibition of 5-HT<sub>2A</sub>-receptor function.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 89(1), 89-92, 2002-05-01

    The Japanese Pharmacological Society

References:  14

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008431168
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    6171034
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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