空腸に内瘻を形成した遺伝性非ポリポーシス大腸癌の1例

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  • A CASE OF HEREDITARY NONPOLYPOSIS COLORECTAL CANCER FORMING JEJUNOCOLIC FISTULA

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A 48-year-old man was seen at the hospital because of sudden diarrhea and weight loss. There were previous histories of a sigmoid colon cancer and descending colon cancer. His father, uncle and brother also had a history of colonic cancers. Barium enema study and colonoscopy showed a cancer of the transverse colon with a fistula to the jejunum and a rectal cancer. Exploratory laparotomy revealed another cecal cancer. Subtotal colectomy with a partial excision of the jejunum was performed. Rectal tumor was resected later by the transsacral approach. Histologically the transverse colon cancer was well differentiated adenocarcinoma and the pathological staging was IIIa such as si, n1, p0, H0 and M(-). The cecal and rectal cancers were in early stage. A detailed family history certified the hereditary nonpolyposis colorectal cancer (HNPCC). The fistula-forming colonic cancers and HNPCC have some similar characteristics as followss: 1) The age of the onset is young. 2) They are often of low malignancy compared to the clinical findings such as local extension and number of lesions. 3) Histologically the rate of mucinous components is relatively high compared to usual colorectal cancers.

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