TRH Stimulation Test in Healthy Elderly: Paradoxical Response of Growth Hormone is Abnormal in Normal Aging.

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  • OHBU Sadayoshi
    the Department of Internal Medicine, St. Luke' s International Hospital
  • YOSHIOKA Narihito
    the Institute for Diabetes Care and Research, Asahi Life Foundation
  • HONDA Masao
    the Department of Neuropsychiatry, Nihon University School of Medicine
  • ANDOH Yukio
    the Department of Internal Medicine, St. Luke' s International Hospital
  • SATO Yuji
    the Department of Neurology, Yokohama City Hospital
  • TAKAO Nobuhiro
    the Department of Internal Medicine, St. Luke' s International Hospital
  • FUKUDA Hiroyuki
    the Department of Internal Medicine, St. Luke' s International Hospital
  • WAKAYAMA Yoshihiro
    the Division of Neurology, Department of Medicine, Showa University Fujigaoka Hospital

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The purpose of this study was to measure TSH (thyrotropin), PRL (prolactin) and GH (growth hormone) response to a TRH (thyrotropin releasing hormone) stimulation test in 37 healthy elderly male subjects and determine if these responses correlate with the incidence of mental decline; and also, to determine if these responses occur more frequently in the elderly than in the general population. A hyperresponse of TSH was documented in 7 of our 37 elderly male subjects, a delayed response of TSH in 4, a low response of PRL in 29 and a significant paradoxical response of GH in 2. Those subjects with a significant paradoxical response of GH were 82 and 83 years of age and their HDS was 20.0 and 25.5, respectively. We did not find a causal relationship between mental decline and the paradoxical response of GH, but our data suggests that the paradoxical response of GH is not normal in elderly older than 80 years old.<br>(Internal Medicine 34:148-152, 1995)

収録刊行物

  • Internal Medicine

    Internal Medicine 34 (3), 148-152, 1995

    一般社団法人 日本内科学会

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