Cytoplasmic Body Myopathy with Hypertrophic Cardiomyopathy

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Author(s)

    • SEKIJIMA Yoshiki
    • The Third Department of Internal Medicine, Shinshu University School of Medicine
    • IKEDA Shu-ichi
    • The Third Department of Internal Medicine, Shinshu University School of Medicine
    • KATAI Satoshi
    • The Third Department of Internal Medicine, Shinshu University School of Medicine
    • MATSUDA Masayuki
    • The Third Department of Internal Medicine, Shinshu University School of Medicine
    • HASHIMOTO Takao
    • The Third Department of Internal Medicine, Shinshu University School of Medicine
    • HARUTA Sei-ichi
    • The Third Department of Internal Medicine, Shinshu University School of Medicine
    • OWA Mafumi
    • The Third Department of Internal Medicine, Shinshu University School of Medicine
    • SAKAI Toshihiko
    • The Second Department of Pathology, Shinshu University School of Medicine
    • YANAGISAWA Nobuo
    • The Third Department of Internal Medicine, Shinshu University School of Medicine

Abstract

A patient with cytoplasmic body myopathy presented muscle hypotonia from birth and developed progressive muscular atrophy and weakness, scoliosis, contracture of joints and cardiorespiratory failure. At the age of 17, he died of heart failure. Post mortem examination revealed severe hypertrophy of cardiac walls and generalized muscular atrophy. Microscopic examination showed many cytoplasmic bodies in skeletal muscle fibers and myofiber disarray in myocardium. No cases of cytoplasmic body myopathy with hypertrophic cardiomyopathy have been reported previously. It is suggested that the Z-line component is related to the formation of the cytoplasmic body in skeletal muscle and disarray in the cardiac muscle.<br>(Internal Medicine 34:166-170, 1995)

Journal

  • Internal Medicine

    Internal Medicine 34(3), 166-170, 1995-03-01

    The Japanese Society of Internal Medicine

References:  30

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