Determination of a Common Clonal Origin of Gastric and Pulmonary Mucosa-Associated Lymphoid Tissue Lymphomas Presenting Five Years Apart

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Author(s)

    • KAWAMATA Norihiko
    • The First Department of Internal Medicine, Tokyo Medical and Dental University
    • MIKI Tohru
    • The First Department of Internal Medicine, Tokyo Medical and Dental University
    • FUKUDA Tetsuya
    • The First Department of Internal Medicine, Tokyo Medical and Dental University
    • SUZUKI Ken
    • The First Department of Internal Medicine, Tokyo Medical and Dental University
    • SUMI Yuki
    • The First Department of Internal Medicine, Tokyo Medical and Dental University
    • OHDAMA Shinichi
    • The First Department of Internal Medicine, Tokyo Medical and Dental University
    • HIROSAWA Shinsaku
    • The First Department of Internal Medicine, Tokyo Medical and Dental University
    • MATSUBARA Osamu
    • The Second Division of Pathology, Tokyo Medical and Dental University
    • AOKI Nobuo
    • The First Department of Internal Medicine, Tokyo Medical and Dental University

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma is often mis-diagnosed as a benign tumor. Dissemination to other sites occurs in MALT lymphoma. We report a 60-year-old man with gastric and pulmonary tumors of MALT lymphoma which occurred 5 years apart. Initially, the gastric tumor had been diagnosed as reactive lymphoreticular hyperplasia. To determine whether the two tumors arose from the same malignant clone, we amplified and sequenced the complementarity-determining region 3 of the immunoglobulin heavy chain gene using the polymerase chain reaction (PCR). The sequences were identical except for 11-nucleotide difference, suggesting identical clonality.<br>(Internal Medicine 34: 220-223, 1995)

Journal

  • Internal Medicine

    Internal Medicine 34(3), 220-223, 1995-03-01

    The Japanese Society of Internal Medicine

References:  15

Cited by:  11

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