Determination of a Common Clonal Origin of Gastric and Pulmonary Mucosa-Associated Lymphoid Tissue Lymphomas Presenting Five Years Apart.

• KAWAMATA Norihiko

  the First Department of Internal Medicine, Tokyo Medical and Dental University

• MIKI Tohru

  the First Department of Internal Medicine, Tokyo Medical and Dental University

• FUKUDA Tetsuya

  the First Department of Internal Medicine, Tokyo Medical and Dental University

• SUZUKI Ken

  the First Department of Internal Medicine, Tokyo Medical and Dental University

• SUMI Yuki

  the First Department of Internal Medicine, Tokyo Medical and Dental University

• OHDAMA Shinichi

  the First Department of Internal Medicine, Tokyo Medical and Dental University

• HIROSAWA Shinsaku

  the First Department of Internal Medicine, Tokyo Medical and Dental University

• MATSUBARA Osamu

  the Second Division of Pathology, Tokyo Medical and Dental University

• KAMIYAMA Ryuichi

  School of Allied Health Sciences, Tokyo Medical and Dental University

• OKI Nobuo

  the First Department of Internal Medicine, Tokyo Medical and Dental University

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma is often mis-diagnosed as a benign tumor. Dissemination to other sites occurs in MALT lymphoma. We report a 60-year-old man with gastric and pulmonary tumors of MALT lymphoma which occurred 5 years apart. Initially, the gastric tumor had been diagnosed as reactive lymphoreticular hyperplasia. To determine whether the two tumors arose from the same malignant clone, we amplified and sequenced the complementarity-determining region 3 of the immunoglobulin heavy chain gene using the polymerase chain reaction (PCR). The sequences were identical except for 11-nucleotide difference, suggesting identical clonality.<br>(Internal Medicine 34: 220-223, 1995)

Journal

• Internal Medicine

  Internal Medicine 34 (3), 220-223, 1995

  The Japanese Society of Internal Medicine

Keywords

• reactive lymphoid hyperplasiav
• polymerase chain reaction
• complementarity-determining region 3

Details

• CRID: 1390282679844165376
• NII Article ID: 10008450505
• NII Book ID: AA10827774
• DOI: 10.2169/internalmedicine.34.220
• COI: 1:STN:280:ByqA3cnpsFw%3D
• ISSN: 13497235
• ISSN: 09182918
• PubMed: 7787333
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine1992/34/3/34_3_220/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1995193011
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed