Variability in Cholesteryl Ester Transfer Protein in Healthy Japanese Hyper-HDL-cholesterolemic Subjects

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Author(s)

Abstract

<i>Objective</i> Hyper-high density lipoprotein (HDL)-cholesterolemia has been considered to be anti-atherogenic and is referred to as longevity syndrome. However, hyper-HDL-cholesterolemia induced by a cholesteryl ester transfer protein (CETP) deficiency may not be athero-protective, rather being atherogenic in nature. In a rural area in central Japan, the incidence of hyper-HDL-cholesterolemia has been found to be rather high (3.1% of healthy people). We studied healthy Japanese people in this area with hyper-HDL-cholesterolemia, particularly in relation to CETP.<br><i>Methods</i> Serum lipids were analyzed, and CETP mass was determined with an enzyme immunoassay method.<br><i>Materials</i> Blood was drawn after an overnight fast from 17 Japanese (5 males and 12 females) with serum HDL-cholesterol (C) ≥100 mg/dl.<br><i>Results</i> Serum CETP mass in hyper-HDL-cholesterolemic subjects was distributed in a wide range. Serum CETP mass was positively correlated with low-density lipoprotein (LDL)-C, apolipoprotein (Apo) B, and LDL-C/HDL-C, with statistical significance. CETP was also positively correlated with LDL-C/Apo B.<br><i>Conclusion</i> These results suggest that hyper-HDL-cholesterolemia may not be a single clinical entity, but a mixture of various pathophysiological conditions, and that the ratio of LDL-C to HDL-C and the size of LDL may be important factors in classifying these conditions.<br>(Internal Medicine 41: 357-359, 2002)

Journal

  • Internal Medicine

    Internal Medicine 41(5), 357-359, 2002-05-01

    The Japanese Society of Internal Medicine

References:  13

Codes

  • NII Article ID (NAID)
    10008450688
  • NII NACSIS-CAT ID (NCID)
    AA10827774
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    09182918
  • NDL Article ID
    6169504
  • NDL Source Classification
    ZS21(科学技術--医学--内科学)
  • NDL Call No.
    Z53-M398
  • Data Source
    CJP  NDL  J-STAGE 
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