Preparation and Antimicrobial Activity of Micacocidin

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Abstract

Micacocidin (<b>3</b>), a Zn-free derivative of micacocidin A (<b>1</b>), was prepared to evaluate its antimicrobial activity in comparison with <b>1</b> and to obtain a starting material for chemical modification of <b>1</b>. The structure of <b>3</b>, quite unlike those of any previously known antimicrobial agents, was elucidated by 1-D and 2-D homonuclear and heteronuclear NMR and mass spectroscopy.<br> Micacocidin (<b>3</b>) thus prepared exhibited weak or no antibacterial activity except against <i>Mycoplasma</i> species, <i>i.e.</i> <b>3</b> showed stronger activity than <b>1</b>. It is noteworthy that <b>3</b> displayed high activity against fungi such as <i>Candida</i>, <i>Aspergillus</i> and <i>Trichophyton</i> species.

Journal

  • The Journal of Antibiotics

    The Journal of Antibiotics 53(5), 532-539, 2000-05-25

    JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

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