6-(Hydroxyalkyl)penicillanates as Probes for Mechanisms of β-Lactamases

Access this Article

Search this Article

Author(s)

    • GOLEMI Dasantila
    • Department of Chemistry and Institute for Drug Design, Wayne State University
    • MAVEYRAUD Laurent
    • Groupe de Cristallographie Biologique, Institut de Pharmacologie et de Biologie Structurale du CNRS
    • ISHIWATA Akihiro
    • Department of Chemistry and Institute for Drug Design, Wayne State University
    • TRANIER Samuel
    • Groupe de Cristallographie Biologique, Institut de Pharmacologie et de Biologie Structurale du CNRS
    • NAGASE Tsuyoshi
    • Department of Chemistry and Institute for Drug Design, Wayne State University
    • MASSOVA Irina
    • Department of Chemistry and Institute for Drug Design, Wayne State University
    • MOUREY Lionel
    • Groupe de Cristallographie Biologique, Institut de Pharmacologie et de Biologie Structurale du CNRS
    • SAMAMA Jean-Pierre
    • Groupe de Cristallographie Biologique, Institut de Pharmacologie et de Biologie Structurale du CNRS

Abstract

6-(Hydroxyalkyl)penicillanates have proven helpful as probes for the mechanisms of β-lactamases, enzymes of resistance for β-lactam antibiotics. The present report summarizes the concepts on design, syntheses and use of these molecules in mechanistic studies of β-lactamases.

Journal

  • The Journal of Antibiotics

    The Journal of Antibiotics 53(10), 1022-1027, 2000-10-25

    JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

References:  19

Codes

Page Top