Bioxanthracenes from the Insect Pathogenic Fungus Cordyceps pseudomilitaris BCC 1620. I. Taxonomy, Fermentation, Isolation and Antimalarial Activity.

  • JATURAPAT AMONLAYA
    National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA)
  • ISAKA MASAHIKO
    National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA)
  • HYWEL-JONES NIGEL L.
    National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA)
  • LERTWERAWAT YUWAPIN
    National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA) School of Bioresources and Technology, King Monkot's University of Technology Thonburi
  • KAMCHONWONGPAISAN SUMALEE
    National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA)
  • KIRTIKARA KANYAWIM
    National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA)
  • TANTICHAROEN MORAKOT
    National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA) School of Bioresources and Technology, King Monkot's University of Technology Thonburi
  • THEBTARANONTH YODHATHAI
    National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA) Department of Chemistry, Faculty of Science, Mahidol University

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  • I. Taxonomy, Fermentation, Isolation and Antimalarial Activity

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Abstract

Eleven bioxanthracenes and two monomers, six novel in nature, were isolated from the insect pathogenic fungus Cordyceps pseudomilitaris BCC 1620. Growth optimization of the strain led to the improvement of bioxanthracenes production. The bioxanthracenes were evaluated for their antimalarial activity and cytotoxicity.

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