Extremophilic Organisms as an Unexplored Source of Antifungal Compounds

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Abstract

Extracts of the biomasses and fermentation broths of 217 extremophilic microorganisms isolated from a number of locales were screened for antifungal activity using whole-cell and mechanism-based <i>in vitro</i> assays. Importantly, eleven broth extracts had activity against several <i>Candida</i> species and <i>Aspergillus fumigatus</i> in whole-cell <i>in vitro</i> assays. One broth specifically inhibited (1, 3)β-glucan synthase activity and four specifically inhibited ketol-isomefase activity, suggesting a mode of action of the antifungal compound(s) present in these extracts. The extract from one thermophile, a novel species of <i>Pseudomonas</i>, was fractionated, an active compound purified and its structure determined. The compound was identified as pyochelin, a previously identified iron-binding compound with heretofore undescribed antifungal activity. To our knowledge, this is the first report demonstrating that extremophiles synthesize compounds that have antifungal activity.

Journal

  • The Journal of Antibiotics

    The Journal of Antibiotics 54(1), 56-65, 2001-01-25

    JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

References:  29

Cited by:  4

Codes

  • NII Article ID (NAID)
    10008469435
  • NII NACSIS-CAT ID (NCID)
    AA0069330X
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00218820
  • Data Source
    CJP  CJPref  J-STAGE 
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