TPU-0031-A and B, New Antibiotics of the Novobiocin Group Produced by Streptomyces sp. TP-A0556.

• SASAKI TOMOMITSU

  Biotechnology Research Center, Toyama Prefectural University

• IGARASHI YASUHIRO

  Biotechnology Research Center, Toyama Prefectural University

• SAITO NORIKO

  National Institute of Infectious Diseases

• FURUMAI TAMOTSU

  Biotechnology Research Center, Toyama Prefectural University

抄録

Two novel antibiotics, TPU-0031-A and B, were isolated from the culture broth of an actinomycete strain. The producing strain, TP-A0556, was identified as Streptomyces sp. based on the taxonomic study. The new antibiotics were obtained by solvent extraction and chromatographic purification. Spectroscopic analyses showed that TPU-0031-A and B were 7'-demethylnovobiocin and 5′′-demethylnovobiocin, respectively. These compounds showed antibiotic activity against Gram-positive and -negative bacteria.

収録刊行物

• The Journal of Antibiotics

  The Journal of Antibiotics 54 (5), 441-447, 2001

  公益財団法人 日本感染症医薬品協会

キーワード

• Drug Discovery
• Pharmacology

詳細情報

• CRID: 1390001204151833344
• NII論文ID: 130003410411
• NII論文ID: 10008470342
• NII書誌ID: AA0069330X
• DOI: 10.7164/antibiotics.54.441
• COI: 1:CAS:528:DC%2BD3MXjvF2isLw%3D
• ISSN: 18811469
• ISSN: 00218820
• ISSN: http://id.crossref.org/issn/00218820
• PubMed: 11480888
• Web Site: https://search.jamas.or.jp/link/ui/2001236789
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可