SW-163C and E, Novel Antitumor Depsipeptides Produced by Streptomyces sp. I. Taxonomy, Fermentation, Isolation and Biological Activities.

• KUROSAWA KAZUHKO

  Rescarch Institute of Life Science, Snow Brand Milk Products Co., Ltd.

• TAKAHASHI KOSAKU

  Rescarch Institute of Life Science, Snow Brand Milk Products Co., Ltd.

• TSUDA EISUKE

  Rescarch Institute of Life Science, Snow Brand Milk Products Co., Ltd.

Bibliographic Information

Other Title

• I. Taxonomy, Frmentation, Isolation and Biological Activities

Abstract

Novel depsipeptides, SW-163C and E were isolated from the culture broth of an actinomycete strain. The producing organism, designated as SNA15896, was identified as a member of Streptomyces from its morphological and cultural characteristics. SW-163C and E exhibited potent antitumor activities against various tumor cell lines in vitro and against murine leukemia P388 in vivo. The compounds also showed antimicrobial activities.

Journal

• The Journal of Antibiotics

  The Journal of Antibiotics 54 (8), 615-621, 2001

  JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

Keywords

• Drug Discovery
• Pharmacology

Details

• CRID: 1390282679126480768
• NII Article ID: 130003410418
• NII Article ID: 10008470652
• NII Book ID: AA0069330X
• DOI: 10.7164/antibiotics.54.615
• COI: 1:CAS:528:DC%2BD3MXmsVehsbg%3D
• ISSN: 18811469
• ISSN: 00218820
• ISSN: http://id.crossref.org/issn/00218820
• PubMed: 11592497
• Web Site: https://search.jamas.or.jp/link/ui/2002047817
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed