Chlorogentisylquinone, a New Neutral Sphingomyelinase Inhibitor, Produced by a Marine Fungus.

• UCHIDA RYUJI

  Kitasato Institute for Life Sciences, Kitasato University and The Kitasato Institute

• TOMODA HIROSHI

  Kitasato Institute for Life Sciences, Kitasato University and The Kitasato Institute

• ARAI MASAYOSHI

  Kitasato Institute for Life Sciences, Kitasato University and The Kitasato Institute

• OMURA SATOSHI

  Kitasato Institute for Life Sciences, Kitasato University and The Kitasato Institute

抄録

Chlorogentisylquinone, a new inhibitor of neutral Sphingomyelinase activity, was purified from the culture broth of a fungal strain FOM-8108 isolated from a marine environment by solvent extraction, silica gel chromatography and Sephadex LH-20 chromatography. Its chemical structure was elucidated by spectroscopic studies including ¹H, ¹³C, DEPT, HMQC and HMBC NMR experiments. Chlorogentisylquinone inhibited neutral Sphingomyelinase activity of rat brain membranes with an IC₅₀ value of 1.2μM.

収録刊行物

• The Journal of Antibiotics

  The Journal of Antibiotics 54 (11), 882-889, 2001

  公益財団法人 日本感染症医薬品協会

キーワード

• Drug Discovery
• Pharmacology

詳細情報

• CRID: 1390282679127588608
• NII論文ID: 130003410391
• NII論文ID: 10008471263
• NII書誌ID: AA0069330X
• DOI: 10.7164/antibiotics.54.882
• COI: 1:CAS:528:DC%2BD3MXovVOru74%3D
• ISSN: 18811469
• ISSN: 00218820
• PubMed: 11827029
• Web Site: https://search.jamas.or.jp/link/ui/2002117999
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可