Stidies on the Biosynthesis of Epothilones : Hydroxylation of Epo A and B to epothilones E and F

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Author(s)

    • GERTH Klaus
    • GBF, Gesellschaft fur Biotechnologische Forschung mbH, Abteilung Naturstoffbiologie
    • STEINMETZ Heinrich
    • GBF, Gesellschaft fur Biotechnologische Forschung mbH, Abteilung Naturstoffchemie
    • HOFLE Gerhard
    • GBF, Gesellschaft fur Biotechnologische Forschung mbH, Abteilung Naturstoffchemie
    • RECHENBACH Hans
    • GBF, Gesellschaft fur Biotechnologische Forschung mbH, Abteilung Naturstoffbiologie

Abstract

When <i>Sorangium cellulosum</i> So ce90 is grown without XAD adsorber resin there is a steady state of epothilone A and B biosynthesis and hydroxylation of these products to epothilones E and F. This biotransformation at position C-21 of the thiazole ring is not restricted to producers of epothilones. It is carried out by a substrate induced monooxygenase. Epothilones E and F are further degraded by opening of the lactone ring by an esterase. Steps of degradation of different strains of <i>S. cellulosum</i> are compared.

Journal

  • The Journal of Antibiotics

    The Journal of Antibiotics 55(1), 41-45, 2002-01-25

    JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008471810
  • NII NACSIS-CAT ID (NCID)
    AA0069330X
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00218820
  • Data Source
    CJP  CJPref  J-STAGE 
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