Stidies on the Biosynthesis of Epothilones : Hydroxylation of Epo A and B to epothilones E and F
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When <i>Sorangium cellulosum</i> So ce90 is grown without XAD adsorber resin there is a steady state of epothilone A and B biosynthesis and hydroxylation of these products to epothilones E and F. This biotransformation at position C-21 of the thiazole ring is not restricted to producers of epothilones. It is carried out by a substrate induced monooxygenase. Epothilones E and F are further degraded by opening of the lactone ring by an esterase. Steps of degradation of different strains of <i>S. cellulosum</i> are compared.
- The Journal of Antibiotics
The Journal of Antibiotics 55(1), 41-45, 2002-01-25
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION