SNF4435C and D, Novel Immunosuppressants Produced by a Strain of Streptomyces spectabilis. III. Immunosuppressive Efficacy.

DOI PubMed 参考文献15件
  • KUROSAWA KAZUHIKO
    Research Institute of Life Science, Snow Brand Milk Products Co., Ltd. National Food Research Institute
  • TAKAHASHI KOSAKU
    Research Institute of Life Science, Snow Brand Milk Products Co., Ltd. National Food Research Institute
  • FUJISE NOBUAKI
    Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
  • YAMASHITA YASUSHI
    Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
  • WASHIDA NAOHIRO
    Research Institute of Life Science, Snow Brand Milk Products Co., Ltd. Daiichi Pharmaceutical Co., Ltd.
  • TSUDA EISUKE
    Research Institute of Life Science, Snow Brand Milk Products Co., Ltd. Biological Research Laboratories, Sankyo Co., Ltd.

書誌事項

タイトル別名
  • III. Immunosuppressive Efficacy

この論文をさがす

抄録

Novel immunosuppressants, SNF4435C and D produced by a strain of Streptomyces spectabilis, were examined for their pharmacodynamical profiles. SNF4435C and D suppressed the responses of both murine splenocytes and human peripheral blood lymphocytes in the mixed lymphocyte reaction (MLR) with IC50 values of 0.5μM and 0.2μM, respectively. In the mouse MLR experiments, SNF4435C and D did not block the production of interleukin-2 (IL-2) and the compounds-induced suppression was not restored by the addition of exogeneous IL-2. In addition, the significant inhibitory action was still retained even when SNF4435C or D was added after 48 hours from the start of the culture. These results were distinct from the behaviors observed with FK-506. SNF4435C, the major component, suppressed mouse delayed type hypersensitivity (DTH) and prolonged rat skin allograft survival.

収録刊行物

参考文献 (15)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ