Migrastatin and a New Compound, Isomigrastatin, from Streptomyces platensis.

• WOO ELAINE J.

  Kosan Biosciences, Inc.

• STARKS COURTNEY M.

  Kosan Biosciences, Inc.

• CARNEY JOHN R.

  Kosan Biosciences, Inc.

• ARSLANIAN ROBERT

  Kosan Biosciences, Inc.

• CADAPAN LAWRENCE

  Kosan Biosciences, Inc.

• ZAVALA STEFAN

  Kosan Biosciences, Inc.

• LICARI PETER

  Kosan Biosciences, Inc.

抄録

Streptomyces platensis (strain NRRL 18993), a producer of dorrigocins, was shown to produce migrastatin, a cyclic congener of dorrigocin A previously reported from a different organism. Additionally a new compound isomeric to migrastatin, isomigrastatin, was also isolated and its structure was determined to be a cyclic form of dorrigocin B. Both compounds were fully characterized from MS and NMR data. Product titers of both were improved by the addition of XAD-16 resin to the fermentation medium.

収録刊行物

• The Journal of Antibiotics

  The Journal of Antibiotics 55 (2), 141-146, 2002

  公益財団法人 日本感染症医薬品協会

キーワード

• Drug Discovery
• Pharmacology

詳細情報

• CRID: 1390001204151367168
• NII論文ID: 130003503944
• NII論文ID: 10008471989
• NII書誌ID: AA0069330X
• DOI: 10.7164/antibiotics.55.141
• COI: 1:CAS:528:DC%2BD38XitVeit78%3D
• ISSN: 18811469
• ISSN: 00218820
• PubMed: 12002995
• Web Site: https://search.jamas.or.jp/link/ui/2002188570
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可