Watasemycins A and B, New Antibiotics Produced by Streptomyces sp. TP-A0597.

• SASAKI TOMOMITSU

  Biotechnology Research Center, Toyama Prefectural University

• IGARASHI YASUHIRO

  Biotechnology Research Center, Toyama Prefectural University

• SAITO NORIKO

  National Institute of Infectious Diseases

• FURUMAI TAMOTSU

  Biotechnology Research Center, Toyama Prefectural University

抄録

Two novel antibiotics, watasemycins A and B, were isolated from the fermentation broth of an actinomycete strain. The producing strain TP-A0597 was isolated from the seawater sample collected in Toyama Bay, Japan and identified as Streptomyces sp. based on the taxonomic study. The new antibiotics were obtained by solvent extraction and chromatographic purification and spectroscopic analyses identified that they were new analogs of thiazostatins. Watasemycin possesses a methyl group at 5'-position of thiazostatin instead of a hydrogen atom. Watasemycins showed antibiotic activity against Gram-positive and negative bacteria and yeast.

収録刊行物

• The Journal of Antibiotics

  The Journal of Antibiotics 55 (3), 249-255, 2002

  公益財団法人 日本感染症医薬品協会

キーワード

• Drug Discovery
• Pharmacology

詳細情報

• CRID: 1390282679127771648
• NII論文ID: 130003503957
• NII論文ID: 10008472202
• NII書誌ID: AA0069330X
• DOI: 10.7164/antibiotics.55.249
• COI: 1:CAS:528:DC%2BD38Xis1aisb4%3D
• ISSN: 18811469
• ISSN: 00218820
• ISSN: http://id.crossref.org/issn/00218820
• PubMed: 12014439
• Web Site: https://search.jamas.or.jp/link/ui/2002189830
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可