Severe Hypertriglyceridemia Induced by Tamoxifen.
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- Taira Mika
- Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
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- Takasu Nobuyuki
- Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
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- Komiya Ichiro
- Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
Bibliographic Information
- Other Title
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- Tamoxifen投与中にトリグリセリドの著増を認めた1例
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Abstract
A 71-year-old woman was admitted to our hospital because of severe hypertriglyceridemia. The patient had a 26-year history of non-insulin-dependent diabetes mellitus and hyperlipidemia (T-chol 300mg/dl, TG 300mg/dl). She was treated with sulfonylurea and clofibrate. Seven years before admission, she had undergone a radical mastectomy for cancer of the left breast. After the operation, she had received tamoxifen and fluorouracil. One month before admission, she had marked hypertriglyceridemia (triglyceride 2, 106mg/dl). After discontinuation of tamoxifen and fluorouracil, her serum triglyceride level decreased to 372mg/dl; when tamoxifen was given again, it increased to 581mg/dl, and her hepatic triglyceride lipase activity decreased from 0.228 to 0.164μmol FFA/ml/min. Apolipoprotein E phenotype was wild type E3/3. The concentration of sex-hormone-binding globulin increased from 110 to 130nmol/l. These changes associated with tamoxifen treatment were similar to those seen after administration of estrogen. Tamoxifen, an anti-estrogen, has been used as adjuvant therapy in cases of estrogen-receptor-positive breast cancer. Tamoxifen has some weak estrogenic activity. The tamoxifen-induced hypertriglyceridemia seen in this case was an effect of its estrogenic action.
Journal
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- Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
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Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 35 (11), 858-860, 1998
The Japan Geriatrics Society
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Details 詳細情報について
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- CRID
- 1390001205020483840
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- NII Article ID
- 10008483307
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- NII Book ID
- AN00199010
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- ISSN
- 03009173
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- PubMed
- 10064974
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed