-
- 名倉 英一
- 国立療養所中部病院・長寿医療研究センター内科
-
- 南 三郎
- 名古屋第一日赤病院内科
-
- 永田 紘一郎
- 安城更生病院内科
-
- 森下 剛久
- 江南昭和病院内科
-
- 竹山 英夫
- 名古屋掖済会病院内科
-
- 佐尾 浩
- 名鉄病院内科
-
- 鈴木 久三
- 市立岡崎病院内科
-
- 直江 知樹
- 名古屋大学医学部附属病院難治感染症部
-
- 横幕 省三
- 愛知三の丸病院内科
-
- 水野 晴光
- 社会保険中京病院血液科
-
- 村瀬 卓平
- トヨタ記念病院血液科
-
- 平林 憲之
- 名古屋第二日赤病院血液科
-
- 城川 容子
- 国立療養所中部病院・長寿医療研究センター内科
-
- 谷本 光音
- 名古屋大学医学部第一内科
-
- 川島 康平
- 名古屋大学医学部第一内科
-
- 斎藤 英彦
- 名古屋大学医学部第一内科
書誌事項
- タイトル別名
-
- Analysis of Elderly Patients, Aged 60 Years Old or over, with Acute Lymphoblastic Leukemia.
- 60サイ イジョウ ノ コウレイシャ キュウセイ リンパセイ ハッケツビョウ ノ リンショウテキ ケントウ
この論文をさがす
抄録
In order to obtain the realistic background information on clinical features, and the present status of treatment and outcome in elderly patietnts with acute lymphoblastic leukemia (ALL), we carried out random survey of patients with ALL aged 60 or over who had been admitted to 13 general hospitals in the Nagoya region from January 1990 through December 1995.<br>Among the 20 cases collected, ages ranged from 60 to 88 (median age 68), and the male to female ratio was 11: 9. Nineteen cases were L2 subtype in FAB classification. Among 17 patients, 13 had B cell series surface phenotypes (76%), 2 had T cell series (12%), one had stem cell type (6%) and one had an undetermined phenotype (6%). Ph chromosomes were detected in 4 cases among 15 analized (27%), whereas 5 were found to have no chromosomal abnormality. Half of the patients had some concurrent disease at diagnosis, including two with treatment-limiting complicatioms.<br>Common induction regimens were the combination of adriamycin (ADM)+vincristine (VCR)+cyclophosphamide (CPM)+mitoxdn trone+L-asparaginase [4 patients], ADM+VCR+PSL [4 patients], VCR+PSL [4 patients] and others [8 patients]. The overall remission rate was 55.0% (11/20) without any significant difference according to age. The median survival time (MST) for all cases was 205 days (1-year survivial rate: 17.9%, 2-year survival rate: 10.8%). There was no significant differrence in survival times among patients with the Ph chromosome, those with other chromosomal abnormalities and those without them. All the patients aged 75 or over were treated with attenuated induction therapy, and they had a shorter survivial than those aged less than 75, but with no statistical siginificance [MST; 121 days versus 276 days, p=0.307 (generalized Wilcoxon test)].
収録刊行物
-
- 日本老年医学会雑誌
-
日本老年医学会雑誌 36 (1), 52-58, 1999
一般社団法人 日本老年医学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001205022029568
-
- NII論文ID
- 130003652471
- 10008483696
-
- NII書誌ID
- AN00199010
-
- NDL書誌ID
- 4699207
-
- ISSN
- 03009173
-
- PubMed
- 10332195
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可