降圧薬療法下通院中の老年者高血圧患者の３年間予後に関する多施設調査　　脳心血管疾患および悪性疾患の発症・死亡について

DOI Web Site PubMed 被引用文献1件 参考文献18件

書誌事項

タイトル別名
  • Multicenter Prospective Survey of Prognosis of Hypertensive Elderly Outpatient under Antihypertesive Treatment. Morbidity and Mortality of Cardiovascular Diseases and Cancer.
  • コウアツヤク リョウホウ カツウイン チュウ ノ ロウネンシャ コウケツアツ カンジャ ノ 3ネンカン ヨゴ ニ カンスル タシセツ チョウサ ノウ シンケッカン シッカン オヨビ アクセイ シッカン ノ ハッショウ シボウ ニ ツイテ
  • Morbidity and Mortality of Cardiovascular Diseases and Cancer
  • 脳心血管疾患および悪性疾患の発症・死亡について

この論文をさがす

抄録

Although calcium-channel blockers and angiotensin-I-converting enzyme inhibitors are often used for treatment of hypertension in the elderly in Japan compared to those in the United States and in European countries, there have been few investigations on the prognosis of the elderly receiving these antihypertensive treatments. The Research Group for “Guidelines on the Treatment of Hypertension in the Elderly” collaborated with the Comprehensive Research Projects on Aging and Health group of the Ministry of Health and Welfare of Japan in performing a 3-year survey on the outcome of 700 hypertensive elderly outpatients (≥60 years) receiving treatment of antihypertensive drugs. Antihypertensive drugs including dihydropyridine-type calcium cannel blockers, beta blockers, angiotensin-I-converting enzyme inhibitors, diltiazem, diuretics and old-type antihypertensives (hydralazine, budralazine, and centrally acting drugs such as clonidine, methyldopa and guanabenz) were administered to 71.3%, 30.4%, 26.2%, 14.0%, 8.6%, and 6.4% of the 642 elderly patients surveyed for three years, at the time of registration, respectively. Morbidity and mortality rates of total cerebro-cardiovascular diseases, stroke, and heart diseases, were 27.6 and 7.81/1, 000 patient-years, 15.1 and 3.6/1, 000 patient-years, 10.4 and 4.2/1, 000 patient-years, respectively. These results were similar or even better than those of megatrials of antihypertensive treatments for elderly patients in Europe and United States. After adjustment for potential confounding factors, multiple logistic analysis revealed that a past history of ischemic heart disease, use of the old-type antihypertensive drugs, male gender, and diastolic high blood pressure were independent risk factors for the morbidity of cerebro-cardiovascular diseases taking the group of non-cerebro-cardiovascular disease as the reference group. We also identified 22 cases of newly occurred malignancies including 7 fatal cases. However, none of the antihypertensives was significantly related to the occurrence of malignancies. These results lead support to the tendencies in the use of antihypertensive drugs in Japan.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (18)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ