Werner's Syndrome Associated with Progressive Subcortical Vascular Encephalopathy of the Binswanger Type.

DOI PubMed 11 References
  • Kawamura Harukiyo
    Department of Internal Medicine, Chiba University School of Medicine
  • Mori Seijiro
    Department of Internal Medicine, Chiba University School of Medicine
  • Murano Shunichi
    Department of Geriatrics, Akita University School of Medicine
  • Yokote Koutaro
    Department of Internal Medicine, Chiba University School of Medicine
  • Tamura Ken
    Department of Internal Medicine, Chiba University School of Medicine
  • Saito Yasushi
    Department of Internal Medicine, Chiba University School of Medicine

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  • ビンスワンガー型白質脳症を合併し軽度の痴呆症状を呈したウェルナー症候群の１例

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Abstract

A 56-year-old woman with Werner's syndrome was admitted to our hospital because of intractable foot ulcer and malnutrition. She presented dementia consisting of childish behaviour, loss of intelligence, and severe amnesia. Brain CT revealed diffuse periventricular low density areas, and brain MRI also disclosed periventricular high intensity areas under T2-intensified conditions. These findings gave a diagnosis of progressive subcortical vascular encephalopathy of the Binswanger type, which seemed to be the cause of her dementia. She finally died of heart failure due to acute myocardial infarction. Mild to moderate demyelinization was found in the subcortical area of the autopsied cerebrum, confirming the clinical diagnosis. Generalized atherosclerosis characteristic of Werner's syndrome may have predisposed this patient to Binswanger's encephalopathy.

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