高年者のストレス対応 [in Japanese] Coping with Stress in the Elderly [in Japanese]
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Abstract
生物は無生物と異なり, 摩耗 (wear and tear) と修復 (repair and recovery) の動的平衡の下に生を営むものと考えられ, 17-OHCSを摩耗関連物質 (H. Selye) と捉え, 他に修復関連物質をもとめ, 17-Ketosteroid-硫酸 (17-KS-S) にそれを見出した. 17-KS-Sは加齢 (老化), 疾患の進行と共に下降, 心理社会的ストレス, 生活様式の乱れにより下降を示し, 高年者は若年成人と比較し日内変動が少ない. 高年者は配偶者の死亡時に17-KS-S下降, 長期にわたりその低値の持続がみられた. 高年者は若年者に比較し適応能が低いが, 生活様式の改善の事例では17-KS-S上昇がもたらされ, 適応能を高める工夫と可能性が示された.
In terms of adaptability, unlike inanimate objects, living organisms exist in a dynamic balance between “wear and tear” and “repair and recovery”. We regarded 17-hydroxycorticosteroids (17-OHCS) as a compound related to tissue “wear and tear” (Hans Selye) and sought for a compound related to tissue “repair and recovery”. This led us to the discovery of 17-ketosteroid sulfates (17-KS-S) in urine. Elderly persons, unlike young adults, show low levels in 17-KS-S and little diurnal changes. In an elderly person 17-KS-S can decrease on significant life events (e. g.a spouse's death) and remain at low levels for a long time. Elderly persons with frailty need to improve their lifestyle (meals, exercise, rest, sleep, etc.) qualitatively and quantitatively to adapt themselves to stress adequately. Increased 17-KS-S levels were to be related to improvement in lifestyle.
Journal
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- Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
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Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 37(1), 68-73, 2000-01-25
The Japan Geriatrics Society