単独および集団飼育された老齢ラット脳の神経生化学的マーカーの相違

• 江頭 亨

  大分医科大学薬理学教室

書誌事項

タイトル別名

• Effects of Breeding Conditions on Neurochemical Cholinergic and Monoaminergic Markers in Aged Rat Brain.
• タンドク オヨビ シュウダン シイク サレタ ロウレイ ラット ノウ ノ シンケイ セイカガクテキ マーカー ノ ソウイ

抄録

We investigated the effects of breeding conditions on neurochemical markers, muscarinic receptor (mAChR), β-adrenoreceptor (β-AdrR), imipramine binding sites (IMBS), choline acetyltransferase (ChAT), acetylcholinesterase (AChE) and monoamine oxidase (MAO) activity in aged rat brains. An increase of affinity (Kd) and the decrease in the number (Vmax) of mAChR were found in the individual aged rats. Concerning IMBS, Kd and Vmax values increased in the individual aged rats. However, no significant changes were observed in the β-AdrR. The increases of ChAT and MAO activity were found in the aggregated aged rats to compare with in the individual aged rats, while AChE activity decreased in the aggregated aged rats. These changes were also particularly seen in the forebrain of aged rats. These results indicate that the functions of the central nervous system may be reduced in the individual aged rats to compare with in the aggregated aged rats under the breeding conditions.

収録刊行物

• 日本老年医学会雑誌

  日本老年医学会雑誌 37 (3), 233-238, 2000

  一般社団法人 日本老年医学会

キーワード

• 老齢ラット
• 飼育環境
• 神経化学的マーカー
• 受容体
• 酵素活性

詳細情報

• CRID: 1390001205021736320
• NII論文ID: 130003652632
• NII論文ID: 10008487117
• NII書誌ID: AN00199010
• DOI: 10.3143/geriatrics.37.233
• NDL書誌ID: 5357112
• ISSN: 03009173
• PubMed: 10879073
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5357112
• Web Site: https://search.jamas.or.jp/link/ui/2000272909
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可