MULTIDISCIPLINARY TREATMENT FOR A PATIENT WITH UNDIFFERENTIATED THYROID CANCER
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- OHNISHI Hironobu
- Second Department of Surgery, Wakayama Medical School
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- TANIMURA Hiroshi
- Second Department of Surgery, Wakayama Medical School
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- YAMAUE Hiroki
- Second Department of Surgery, Wakayama Medical School
Bibliographic Information
- Other Title
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- 癌集学的治療を行った甲状腺未分化癌の1例
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Abstract
The prognosis of undifferentiated thyroid cancer is extremely poor, and usual postoperative adjuvant therapies including chemotherapy and radiotherapy are almost ineffective. We have given anticancer drugs to such a patient according to the results of chemosensitivity test (SDI method) using highly purified (90%) tumor cells. A 73-year-old woman was admitted to the hospital because of a tumor on the right side of the neck. With a diagnosis of undifferentiated thyroid cancer based on a biopsy, a complete thyroidectomy and lymph nodes dissection were performed. Further extensive surgery was employed for a recurrence. From the excised material, tumor cells were purified up to 90%, for which SDI method was conducted. CDDP and ADM showed higher inhibition rates than other chemotherapeutics. Therefore, intravenous administration of 60mg/m2 of CDDP on the day 1 followed by 40mg/m2 of ADM on the day 4 was designated as one course; and four courses a month were given to the patient for three months. The patient survived for 11 months af-ter the initial operation.<br>It is suggested that appropriate chemotherapeutics selected according to the results of chemosensitivity testing may contribute to improve the prognosis of patients with undifferentiated thyroid cancer.
Journal
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- Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)
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Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 60 (8), 2051-2056, 1999
Japan Surgical Association
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Details 詳細情報について
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- CRID
- 1390282679829347072
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- NII Article ID
- 130003601478
- 10008495978
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- NII Book ID
- AA11189709
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- ISSN
- 18825133
- 13452843
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed