MULTIDISCIPLINARY TREATMENT FOR A PATIENT WITH UNDIFFERENTIATED THYROID CANCER

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  • 癌集学的治療を行った甲状腺未分化癌の1例

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Abstract

The prognosis of undifferentiated thyroid cancer is extremely poor, and usual postoperative adjuvant therapies including chemotherapy and radiotherapy are almost ineffective. We have given anticancer drugs to such a patient according to the results of chemosensitivity test (SDI method) using highly purified (90%) tumor cells. A 73-year-old woman was admitted to the hospital because of a tumor on the right side of the neck. With a diagnosis of undifferentiated thyroid cancer based on a biopsy, a complete thyroidectomy and lymph nodes dissection were performed. Further extensive surgery was employed for a recurrence. From the excised material, tumor cells were purified up to 90%, for which SDI method was conducted. CDDP and ADM showed higher inhibition rates than other chemotherapeutics. Therefore, intravenous administration of 60mg/m2 of CDDP on the day 1 followed by 40mg/m2 of ADM on the day 4 was designated as one course; and four courses a month were given to the patient for three months. The patient survived for 11 months af-ter the initial operation.<br>It is suggested that appropriate chemotherapeutics selected according to the results of chemosensitivity testing may contribute to improve the prognosis of patients with undifferentiated thyroid cancer.

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