von Recklinghausen病に乳癌と無症候型褐色細胞腫を合併した1例

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  • BREAST CANCER AND ASYMPTOMATIC PHEOCHRMOCYTOMA ASSOCIATED WITH VON RECKLINGHAUSEN'S DISEASE IN ONE CASE

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We have encountered a rare case of breast cancer and asymptomatic phechromocytoma associated with von Recklinghausen's disease.<br> A 46-year-old woman was referred to our hospital because of a left breast lump. She had cafe au lait maculae and multiple neurofibromas since her youth. Physical examination revealed a tumor, measuring 4.0×4.0cm, in the upper half of the left breast. Aspiration cytology offered a diagnosis of breast cancer (Stage II). The operation (Bt+Ax) was done. Histopathological examination revealed papillotubular carcinoma with lymph node metastasis (n1α) and the skin tumor was neurofibroma. ER and PgR were positive. After the operation, abdominal CT revealed a solitary mass in the right adrenal gland. Laboratory data showed that serum catecholamine levels were normal and urine catecholamine levels were elevated.131I-MIBG scintigraphy showed positive imaging that corresponded with the right adrenal tumor. She has not shown symptoms of hypertension. With a suggested diagnosis of asymptomatic pheochromocytoma, she underwent right adrenectomy, and histopathological examination confirmed pheochromocytoma. She remains disease free 7 months after the operation.

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