Type I collagen cross-linked N-telopeptideおよび Type I collagen cross-linked C-telopeptideによる乳癌骨転移評価  [in Japanese] EVALUATION OF BONE METASTASIS IN BREAST CANCER WITH TYPE I COLLAGEN CROSS-LINKED N-TELOPEPTIDE AND TYPE I COLLAGEN CROSS-LINKED C-TELOPEPTIDE  [in Japanese]

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    • 尾浦 正二 OURA Shoji
    • 和歌山県立医科大学第1外科 Department of Thoracic and Cardiovascular Surgery, Wakayama Medical College


骨転移ないし骨浸潤を有する女性乳癌患者30例を対象にType I collagen cross-linked N-telopeptide (NTx)の骨転移診断能をType I collagen cross-linked C-telopeptide (I CTP)と比較検討した. NTxおよびI CTPは,共に骨病変個数が増加するにつれ高値を示したが,骨病変個数との相関はI CTPの方が良好であった. NTxおよびI CTPは,乳癌術後非担癌患者に比較して骨病変を有する症例で高値を示したが,骨病変陽性例でcut off値以上を示す割合は, NTxが16.7%であったのに対し, I CTPでは56.7%であった.また骨病変が良好に制御されている症例と制御不良な症例を比較すると, I CTPでは後者が前者の2倍, NTxでは1.7倍の値を示した.しかしながらNTxにおいては,骨病変の制御不良症例でも平均値がcut off以下であった.以上より,乳癌骨病変診断能は, NTxよりもI CTPの方が優れていると思われる.

Diagnostic ability of type I collagen cross-linked N-telopeptide (NTx) against bone metastasis or bone invasion of breast cancer was evaluated in comparison with type I collagen cross-linked C-telopeptide (I CTP). Subjects were 30 female patients with breast cancer having bone metastasis or bone invasion. As the number of bone lesions increased, both NTx and I CTP levels increased. Levels of I CTP correlated better to the number of bone metastatic foci than those of NTx. Each biochemical marker showed higher levels in patients with bone metastasis than in those without bone lesions. Ratios of the patients with above the cut-off level of the biochemical marker were 16.7% in NTx and 56.7% in I CTP. Patients with poorly controlled bone metastasis showed twice the levels than those with well controlled lesions in I CTP, and 1.7-fold the levels in NTx. However, the average of the NTx was smaller than the cut off level even in patients with progressive bone metastasis. In conclusion, I CTP is a more useful biochemical marker than NTx in the diagnosis of bone metastasis in breast cancer.


  • Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 61(2), 291-295, 2000-02-25

    Japan Surgical Association


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