Relation between Hippocampal Damage and Cerebral Cortical Function in Alzheimer's Disease.

• Hanyu Haruo

  Department of Geriatric Medicine, Tokyo Medical University

• Asano Tetsuichi

  Department of Geriatric Medicine, Tokyo Medical University

• Kogure Daiji

  Department of Geriatric Medicine, Tokyo Medical University

• Sakurai Hirofumi

  Department of Geriatric Medicine, Tokyo Medical University

• Iwamoto Toshihiko

  Department of Geriatric Medicine, Tokyo Medical University

• Takasaki Masaru

  Department of Geriatric Medicine, Tokyo Medical University

Bibliographic Information

Other Title

• アルツハイマー病における海馬病変と大脳皮質機能との関連
• アルツハイマービョウ ニ オケル カイバ ビョウヘン ト ダイノウヒシツ キノウ ト ノ カンレン

Abstract

We investigated the relation between hippocampal damage and cerebral cortical dysfunction in Alzheimer's disease (AD) using MRI and SPECT. Nineteen patients with AD and 10 control subjects were studied. Hippocampal damage (including hippocampal formation, entorhinal cortex, and parahippocampal white matter) was assessed to evaluate the severity of atrophy and the magnetization transfer ratio (MTR) and cerebral cortical dysfunction was evaluated by quantitative cerebral blood flow (CBF) measurements using SPECT with 99m Tc-ECD. Compared with controls, patients with AD had significantly more atrophy of the medial temporal lobe and a decrease in MTRs of the hippocampus and parahippocampus. There were significant correlations between the severity of hippocampal damage and regional CBF in temporoparietal lobes. Mini-Mental State Examination scores significantly correlated with the severity of hippocampal damage and regional CBFs in temporoparietal lobes. These results suggest that the functional effect of hippocampal damage occurs in temporoparietal lobes in AD, probably due to neuronal disconnections between hippocampal areas (including the entorhinal cortex) and temporoparietal lobes.

Journal

• Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics

  Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 37 (11), 921-927, 2000

  The Japan Geriatrics Society

Keywords

• Alzheimer's disease
• Hippocampus
• Temporoparietal lobes
• MRI
• SPECT

Details

• CRID: 1390001205021821312
• NII Article ID: 130003652585
• NII Article ID: 10009471742
• NII Article ID: 10008505883
• NII Book ID: AN00199010
• DOI: 10.3143/geriatrics.37.921
• NDL BIB ID: 5594517
• ISSN: 03009173
• PubMed: 11193370
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5594517
• Web Site: https://search.jamas.or.jp/link/ui/2001096259
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed