The Effect of Celiprolol Hydrochloride for Lipid Metabolism. Especially for the Low Density Lipoprotein Particle Size.
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- Totsuka Mitsuya
- Department of Internal Medicine, Toho University, Sakura Hospital
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- Miyashita Yoh
- Department of Internal Medicine, Toho University, Sakura Hospital
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- Ito Yoshiaki
- Department of Internal Medicine, Toho University, Sakura Hospital
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- Oyama Tomokazu
- Department of Internal Medicine, Toho University, Sakura Hospital
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- Hashiguti Shouichirou
- Department of Internal Medicine, Toho University, Sakura Hospital
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- Watanabe Hitoshi
- Department of Clinical Laboratory Medicine, Toho University, Sakura Hospital
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- Shirai Kohji
- Department of Clinical Laboratory Medicine, Toho University, Sakura Hospital
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- Ban Toshiaki
- Kokuho Kuniyoshi Hospital
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- Ishihara Hiroyuki
- Kokuho Kuniyoshi Hospital
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- Yamamoto Kazuo
- Kokuho Kuniyoshi Hospital
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- Kawano Eiichirou
- Kokuho Kuniyoshi Hospital
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- Kanechi Masatoshi
- Kokuho Kyonan Hospital
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- Mori Jou
- Kokuho Kyonan Hospital
Bibliographic Information
- Other Title
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- Celiprolol hydrochlorideの脂質代謝に及ぼす影響(特にlow density lipoproteinのサイズ変化について)
- Celiprolol hydrochloride ノ シシツ タイシャ ニ オヨボス エイキョウ トクニ low density lipoprotein ノ サイズ ヘンカ ニ ツイテ
- Especially for the Low Density Lipoprotein Particle Size
- 特に low density lipoprotein のサイズ変化について
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Abstract
Recently, much attention has been paid to small sized low density lipoprotein (LDL) as a risk factor for ischemic heart disease. We investigated the effect of celiprolol hydrochloride (CH), which is a β1 selective β-blocker with high intrinsic sympathomimetic activity (ISA), on the LDL particle size. We treated 41 hypertensive patients with CH and studied the change in LDL particle size according to the score of fast β lipoprotein and LDL relative mobility value (LDL-Rm) measured by lipoprotein polyacrylamide gel disc electrophoresis (PAGE). We also studied changes in blood pressure, total cholesterol (TC), trygiyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and midband on PAGE. Systolic and dyastolic blood pressure and pulse significantly decreased during treatment. TC levels were significantly decreased at 8 weeks in all subjects and at 4, 8 and 12 weeks in patients with a TC value of over 220mg/dl.<br>TG levels were significantly decreased at 4 and 8 weeks in patients with initial levels of over 150mg/dl, and significantly increased at 4 and 8 weeks in those with initial levels of under 150mg/dl of TG. HDL-C levels did not significantly change during treatment.<br>LDL-C levels were significantly decreased at 4, 8 and 12 weeks in patients with initial levels of over 150mg/dl. Apo AI, AII, B, CII, CIII and E levels did not significantly change during treatment. Fast β lipoprotein scores did not significantly change overall during treatment, but were significantly decreased at 4 and 8 weeks in patients initial TG levels of over 150mg/dl and at 4 and 12 weeks in those with initial levels of over 220mg/dl of TC. LDL-Rm scores did not significantly change during treatment.<br>Midband scores were significantly reduced overall at 8 weeks, and after 4 and 8 weeks in patients with initial TG levels of over 150m/dl and at 4, 8 and 12 weeks in those with initial TC levels of over 220mg/dl. These results indicated that CH did not change LDL particle size. It was suggested that CH might be a beneficial β-blocker from the standpoint of prevention for atherosclerosis.
Journal
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- Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
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Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 38 (3), 352-359, 2001
The Japan Geriatrics Society
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Details 詳細情報について
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- CRID
- 1390001205021631360
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- NII Article ID
- 130003444466
- 10008506983
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- NII Book ID
- AN00199010
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- NDL BIB ID
- 5776987
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- ISSN
- 03009173
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- PubMed
- 11431890
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed