高齢COPD患者における吸入抗コリン薬の肺機能および生活の質に及ぼす効果  [in Japanese] Effect of Inhaled Anticholinergic Drug on Pulmonary Function and Quality of Life in Elderly Patients with Chronic Obstructive Pulmonary Disease  [in Japanese]

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Author(s)

    • 寺本 信嗣 TERAMOTO Shinji
    • 山王病院内科,国際医療福祉大学臨床医学研究センター Department of Internal Medicine, San-no Hospital, Medical Research Center, International University of Health and Welfare

Abstract

慢性閉塞性肺疾患 (COPD) 患者における抗コリン薬吸入の呼吸生理学的効果と生活の質 (QOL) への影響を評価した. 80歳以上のCOPD患者12名について, 抗コリン薬吸入前後で安静時肺機能, 呼吸筋力を測定し, 運動負荷試験によって運動時換気動態と運動時呼吸困難感を調べた. さらに, 吸入療法前後一カ月の生活の質を評価した. 抗コリン薬吸入によって肺活量, 一秒量が増加し, 残気率が低下した. 呼吸筋力は最大吸気圧 (PImax) が増加した. ボルグスケールで評価した運動時呼吸困難感は Borg scale slope (ΔBS/ΔV<sub>O<sub>2</sub></sub>) が有意の低下を示した. St George's Respiratory Questionnaire で評価したQOLスコアは, 吸入療法一カ月後で改善がみられた. したがって, 高齢COPD患者について, 吸入抗コリン薬療法の導入によって生理学的改善のみならず, QOLの改善も望める可能性が示唆された.

Effects of inhaled anticholinergic drug on the physiological function of the respiratory system and quality of life (QOL) in elderly patients with chronic obstructive pulmonary disease (COPD) have not been fully elucidated. We examined the pulmonary function, static respiratory pressures, and ventilation during exercise, before and after inhalation of oxitropium bromide (OTB) in 12 male patients with COPD (mean age 82.1±0.6 years). QOL was measured with a St George's Respiratory Questionnaire (SGRQ) in the patients. Forced expiratory volume in one second was increased by the inhalation of OTB in the patients, whereas the ratio of residual volume to total lung capacity was decreased by the inhalation. Maximum inspiratory pressure was significantly increased after the administration of OTB. Dyspnea sensation during exercise measured on the Borg scale was reduced by the inhalation of OTB. The scores of SGRQ were improved by one-month treatment with OTB. These results suggest that the treatment with OTB are effective for both physiological function and several aspects of QOL in elderly patients with COPD.

Journal

  • Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics

    Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 38(4), 519-522, 2001-07-25

    The Japan Geriatrics Society

References:  15

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008507406
  • NII NACSIS-CAT ID (NCID)
    AN00199010
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03009173
  • NDL Article ID
    5854768
  • NDL Source Classification
    ZS21(科学技術--医学--内科学)
  • NDL Call No.
    Z19-25
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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