書誌事項
- タイトル別名
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- CHF Arising after Low dose THP-COP Chemotherapy in an Elderly Patient with Malignant Lymphoma.
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A 76-year-old woman was admitted with a one-month history of low grade fever and dizziness. She had a palpable right supraclavicular lymph node. Abdominal ultrasonography showed swollen lymph nodes around the abdominal aorta. A specimen from the right supraclavicular lymph node showed malignant lymphoma (diffuse large B cell type). We started chemotherapy according to the low-dose THP-COP protocol (pirarubicin, cyclophosphamide, vincristine and prednisolone) on the 31st hospital day. Since no adverse effects were detected after two low-dose cycles, the patient received a third course with standard doses on the 87th hospital day. The total dose of pirarubicin was 72mg/m2. Two days after the third course started, she suffered from dyspnea caused by congestive heart failure. A chest X-ray showed advanced cardiomegaly, severe congestion and bilateral pleural effusion. These conditions improved with transvenous administration of diuretics, a vasodilator and phosphodiesterase inhibitor. In this case, congestive heart failure developed even though the total dose of pirarubicin was lower than in previous reports of this complication. When the THP-COP protocol is indicated in elderly patients, cardiotoxicity should be monitored even if the total dose of pirarubicin is very low.
収録刊行物
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- 日本老年医学会雑誌
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日本老年医学会雑誌 38 (4), 548-553, 2001
一般社団法人 日本老年医学会
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詳細情報 詳細情報について
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- CRID
- 1390282679999898496
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- NII論文ID
- 130003444508
- 10008507495
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- NII書誌ID
- AN00199010
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- ISSN
- 03009173
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- PubMed
- 11523171
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
