書誌事項
- タイトル別名
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- A Case of Severe Systemic Edema in an Elderly Hypertensive Patient with Systemic Lupus Erythematodes During Long-term Treatment with Anti-hypertensive Drugs.
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A 71-year-old woman receiving both angiotensin II receptor antagonist and calcium antagonist suffered severe systemic edema. She had been treated for essential hypertension with amlodipine for 2 years and candesartan for 3 months, and systemic lupus erythematodes (SLE) with steroids. During treatment, severe systemic edema appeared, mainly on her face, arms, and legs. At first, we suspected drug-induced edema by candesartan, so it was halted, but the edema still continued. We then considered amlodipine to be the culprit, and finally, the severe systemic edema disappeared after cessation of amlodipine. To control her blood pressure, we recommended candesartan, but 3 months later she suffered severe systemic edema again, thus the causative we drugs of her edema were thought to be both amlodipine and candesartan. Edema is a common symptom in elderly patients and we frequently observe drug-induced edema. In this case, there was underlying acceleration of blood vessel permeability induced by SLE and steroids and moreover, vasodilatation by candesartan and/or amlodipine further accelerated blood vessel permeability, and thus might have caused severe edema. It is very difficult to determine the cause of edema, especially in elderly patients, but we should consider not only one but also two or more drugs as being involved in drug-induced edema.
収録刊行物
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- 日本老年医学会雑誌
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日本老年医学会雑誌 38 (5), 696-699, 2001
一般社団法人 日本老年医学会
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詳細情報 詳細情報について
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- CRID
- 1390282679998500224
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- NII論文ID
- 130003652747
- 10008507951
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- NII書誌ID
- AN00199010
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- ISSN
- 03009173
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- PubMed
- 11605222
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- PubMed
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- 使用不可