加齢に伴う線維化マーカーの変動に関する検討  [in Japanese] Fluctuation of the Fibrosis Markers with Aging  [in Japanese]

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Author(s)

    • 江藤 奈緒 ETO Nao
    • 藤田保健衛生大学第2病院内科 Department of Internal Medicine, Second Teaching Hospital, Fujita Health University, School of Medicine
    • 芳野 純治 YOSHINO Junji
    • 藤田保健衛生大学第2病院内科 Department of Internal Medicine, Second Teaching Hospital, Fujita Health University, School of Medicine
    • 乾 和郎 [他] INUI Kazuo
    • 藤田保健衛生大学第2病院内科 Department of Internal Medicine, Second Teaching Hospital, Fujita Health University, School of Medicine
    • 若林 貴夫 WAKABAYASHI Takao
    • 藤田保健衛生大学第2病院内科 Department of Internal Medicine, Second Teaching Hospital, Fujita Health University, School of Medicine
    • 奥嶋 一武 OKUSHIMA Kazumu
    • 藤田保健衛生大学第2病院内科 Department of Internal Medicine, Second Teaching Hospital, Fujita Health University, School of Medicine
    • 小林 隆 KOBAYASHI Takashi
    • 藤田保健衛生大学第2病院内科 Department of Internal Medicine, Second Teaching Hospital, Fujita Health University, School of Medicine
    • 三好 広尚 MIYOSHI Hironao
    • 藤田保健衛生大学第2病院内科 Department of Internal Medicine, Second Teaching Hospital, Fujita Health University, School of Medicine

Abstract

実年齢と身体の加齢は必ずしも比例しない. 老化を年齢以外で評価する指標を見出すことを目的として, 通常肝疾患で測定される4種類の線維化マーカー (ヒアルロン酸, IV型コラーゲン, IV型コラーゲン7S, PIIIP) に着目し, 加齢との関連を検討した. 対象は当院に入院または外来通院中の患者78例であり, 超高齢者群, 高齢者群, 非高齢者群に分け, それぞれの各線維化マーカー値を比較した. 結果, ヒアルロン酸は超高齢者群で86.3±46.7ng/m<i>l</i>, 高齢者群で58.9±37.4ng/m<i>l</i>, 非高齢者群の50~69歳で48.7±71.9ng/m<i>l</i>, 20~49歳で22.6±26.1ng/m<i>l</i>, IV型コラーゲンは超高齢者群で134.6±27.8ng/m<i>l</i>, 高齢者群で131.1±46.5ng/m<i>l</i>, 非高齢者群の50~69歳で135.1±102.1ng/m<i>l</i>, 20~49歳で92.8±21.8ng/m<i>l</i>, IV型コラーゲン・7Sは超高齢者群で4.4±0.9ng/m<i>l</i>, 高齢者群で4.4±0.6ng/m<i>l</i>, 非高齢者群の50~69歳で4.8±1.6ng/m<i>l</i>, 20~49歳で4.3±0.6ng/m<i>l</i>, PIIIPは超高齢者群で0.70±0.31U/m<i>l</i>, 高齢者群で0.64±0.34U/m<i>l</i>, 非高齢者群の50~69歳で0.59±0.43U/m<i>l</i>, 20~49歳で0.46±0.14U/m<i>l</i>であり, ヒアルロン酸, IV型コラーゲン, PIIIPは加齢により上昇する傾向を認めた. とくにヒアルロン酸においてはその傾向が顕著であった. さらに対象 (健診受診者81例) を加え, 各年代におけるヒアルロン酸値を検討した. 結果, 年代が上がるにつれヒアルロン酸値は確実に上昇を示し, 年齢とヒアルロン酸値の間には相関が認められた (相関係数r=0.64, p<0.001). さらに線維化マーカー, 免疫グロブリンや血清アルブミンなど各種項目における加齢への影響について多因子分析を用いて検討したところ, ヒアルロン酸が最も影響しているといった結果であった (p<0.0002, p<0.00002). ヒアルロン酸は実年齢以外で老化を評価する指標になりうると考えられた.

Actual age and biological age are not always proportional. To find out indices of aging, other than actual age, we investigated relationship between aging and four hepatic fibrosis markers: hyaluronates, type IV collagen, type IV collagen 7s and P III P.<br>The subject of this study were 78 patients of inpatients and outpatients of our hospital. They were divided into four groups of very eldery (over 80-year-old), eldery (70-79-year-old), non-eldery (50-69-year-old), and non-eldery (20-49-year-old), and these four groups were compared.<br>The results were as follows: regarding hyaluronates value were 86.3±46.7ng/m<i>l</i> in the patients in the very elderly group, 58.9±37.4ng/m<i>l</i> in the elderly group, 48.7±71.9ng/m<i>l</i> in patients aged between 50 and 69 years old, and 22.6±26.1 ng/m<i>l</i> in patients aged between 20 and 49 years old. Regarding type IV collagen value were 134.6±27.8ng/m<i>l</i> in the very elderly group, 131.1±46.5ng/m<i>l</i> in the elderly group, 135.1±102.1ng/m<i>l</i> in patients aged between 50 and 69 years old and 92.8±21.8ng/m<i>l</i> in patients aged between 20 and 49 years old. Type IV collagen 7s value were 4.4±0.9ng/m<i>l</i> in the very eldery group, 4.4±0.6ng/m<i>l</i> in the elderly group, 4.8±1.6ng/m<i>l</i> in patients of between 50 and 69 years old, and 4.3±0.6ng/ml in patients between 20 and 49 years old. P III P value were 0.70±0.31U/m<i>l</i> in the very elderly group, 0.64±0.34U/m<i>l</i> in the elderly group, 0.59±0.43U/m<i>l</i> in patients aged between 50 and 69 years old, and 0.46±0.14U/m<i>l</i> in patients aged between 20 and 49 years old.<br>The results indicated that three markers: hyaluronates, type IV collagen, P III P increased with the aging. Especially, hyaluronates were remakably increased. Next, we studied 159 patients (78 patients added to 81 patients who visited our hospital for health checkup), and investigated the fluctuation of hyaluronate values by the aging. The results showed a definite increase of hyaluronate values with age. A correlation was recognized between ages and hyaluronate values (correlation coefficient: r=0.64, p<0.001).<br>Furthermore we investigated effect on aging of various items including fibrosis markers, immunoglobulin or serum albumin by using multiple factor analysis, and found that hyaluronates influenced most strongly on aging (p<0.0002, p<0.00002). Thus, hyaluronates could be considered to be an index other than actual ages to evaluate progress of aging.

Journal

  • Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics

    Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 39(2), 176-180, 2002-03-25

    The Japan Geriatrics Society

References:  21

Cited by:  1

Keywords

Codes

  • NII Article ID (NAID)
    10008508399
  • NII NACSIS-CAT ID (NCID)
    AN00199010
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03009173
  • NDL Article ID
    6126029
  • NDL Source Classification
    ZS21(科学技術--医学--内科学)
  • NDL Call No.
    Z19-25
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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