A CLINICOPATHOLOGICAL STUDY OF CASES OF DEATHS DUE TO THYROID CANCER

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  • 甲状腺癌死亡例の臨床病理学的検討

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Abstract

Clinicopathological factors, clinical courses, and causes of deaths were studied in two histologic groups of deceased cases due to thyroid cancer (TC). In a recent 17-year period 198 patients were diagnosed as TC at the hospital and 37 patients of them died. Of the 37 deaths 23 patients died of TC, comprising of 11 patients with differentiated TC(DTC) and 12 with undifferentiated TC(UDTC). Age, clinical stage of the tumor, clinical nodal status, distant metastasis, and pathological tumor stage were important prognostic factors in the TC cases, but sex and pathological nodal status were not significant. Some of the DTC cases died of other causes in their long clinical courses. Due to the repeated recurrence, 3.1 operations on an average were performed to the decrased cases of DTC, but most of the UDTC died in the hospital within 3 months after the first treatment. The clinical findings of the decrased cases and the 11 autopsies indicated that the important causes of the deaths were; dyspnea due to asphyxia and pulmonary metastasis in the DTC, and dyspnea, cahexia and hemorrhage in the UDTC. Multiple distant metastases were found in the several UDTC autopsies, which suggested the UDTC has the character of a systemic disease.

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