CLINICAL ANALYSIS OF 105 PATIENTS WITH HEPATECTOMY FOR LIVER METASTASIS OF COLORECTAL CANCER

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  • 大腸癌肝転移症例に対する肝切除例の検討

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Abstract

One hundred and five patients with liver metastasis from colorectal carcinoma undergone hepatectomy were analized in this study. The three and five year survival rates of 81 patients with curative resection were 41.6% and 27.5%, respectively, whereas the prognosis of non-curatively operated cases were very poor, 50%-survival period of 14 months. The surgical margin of the resected specimen did not correlate with the survival rate but with the disease free survival rate, though none of the following factors such as site of primaries, lymph node metastasis, histological type, time of diagnosis, number or site of metastasis, size of the lesion, and operative method correlated with either. Recurrent disease was observed in 53 patients after hepatectomy, 38 of which showed recurrent lesions in the residual liver. Re-hepatecotmy was performed in 9 cases out of 21 without extra-hepatic recurrence, which showed the comparable result to the first hepatectomy. Continuous intrahepatic arterial infusion with 5FU could be an effective prophylactic chemotherapy for the improvement of the result following hepatectomy. In conclusion, agressive surgical treatments are recommended for the liver metastasis from colorectal primaries when the lesions can be removed completely.

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